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Tedros Adhanom Ghebreyesus’ words came as the US and countries across Europe reported record new cases.
France reported Europe’s highest ever daily figure for the second day in a row, at 208,000 cases.
And the US has reported a record average of 265,427 cases a day over the last week, according to Johns Hopkins.
Denmark, Portugal, the UK and Australia have all also reported record-breaking figures.
Poland reported 794 Covid-related deaths on Wednesday, the highest number in its fourth wave of the pandemic. More than three-quarters of these were unvaccinated people.